Experimental radioimmunotherapy of small peritoneal metastases of colorectal origin
نویسندگان
چکیده
منابع مشابه
Combination therapy using gemcitabine and radioimmunotherapy in nude mice with small peritoneal metastases of colonic origin.
INTRODUCTION Gemcitabine has been shown to exert a radiosensitizing effect in various epithelial cancers. The aim of the present studies was to investigate whether the efficacy of radioimmunotherapy (RIT) using the (131)I-labeled anti-CEA monoclonal antibody (MAb) MN-14 could be enhanced by coadministration of gemcitabine in nude mice with small (1-3 mm) peritoneal metastases of colonic origin....
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We have previously shown that, monoclonal antibodies (mAbs) labeled with the Auger electron emitter I are more in vitro, 125 cytotoxic if they remain at the cell surface and do not internalize in the cytoplasm. Here, we assessed the biological efficiency in vivo of internalizing and non internalizing I-labeled mAbs for the treatment of small solid tumors. 125
متن کاملTreatment of peritoneal metastases from colorectal cancer
Peritoneal seedings of a colorectal tumor represent the second most frequent site of metastasis (after the liver). In the era of 5-fluorouracil (5-FU)-only chemotherapy, the prognosis was poor for colorectal cancer with peritoneal metastases. Within the last few years, new chemotherapeutic and targeted agents have improved the prognosis; however, the response to these treatments seems to be low...
متن کاملImmunohistochemistry – Microarray Analysis of Patients with Peritoneal Metastases of Appendiceal or Colorectal Origin
BACKGROUND The value of immunohistochemistry (IHC)-microarray analysis of pathological specimens in the management of patients is controversial, although preliminary data suggest potential benefit. We describe the characteristics of patients undergoing a commercially available IHC-microarray method in patients with peritoneal metastases (PM) and the feasibility of this technique in this populat...
متن کاملExperimental study of radioimmunotherapy versus chemotherapy for colorectal cancer.
BACKGROUND Radioimmunotherapy (RIT) has been shown to reduce the incidence of local recurrence of colorectal cancer in an experimental model. The aim of the present study was to investigate the survival benefit of RIT compared with chemotherapy. METHODS An anastomosis was constructed in male Wag/Rij rats after intraluminal injection of CC531 tumour cells. The therapeutic efficacy of (177) Lu-...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2003
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.11304